A Brain-Based Measure of Anxiety Sensitivity

Grant number: 1025619 | Funding period: 2012 - 2014

Completed

Abstract

Excessive anxiety is disabling, such that people who suffer from a clinical anxiety disorder are often crippled by overwhelming emotional and physical symptoms. We will use sophisticated brain imaging technology to understand how certain brain areas produce feelings of anxiety, including a common fear of arousal related bodily sensations. This work is expected to enhance our basic understanding of the brain basis of anxiety symptoms and may inform new treatment options with biological rationale.

Related publications (6)

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Prefrontal-amygdala connectivity in trait anxiety and generalized anxiety disorder: Testing the boundaries between healthy and pathological worries

D Porta-Casteràs, MA Fullana, D Tinoco, I Martínez-Zalacaín, J Pujol, DJ Palao, C Soriano-Mas, BJ Harrison, E Via, N Cardoner

2020-04-15

Background: Current brain-based theoretical models of generalized anxiety disorder (GAD) suggest a dysfunction of amygdala-ventrom..

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Ventromedial prefrontal cortex activity and pathological worry in generalised anxiety disorder

E Via, MA Fullana, X Goldberg, D Tinoco-González, I Martínez-Zalacaín, C Soriano-Mas, CG Davey, JM Menchón, B Straube, T Kircher, J Pujol, N Cardoner, BJ Harrison

2018-07-01

Background Pathological worry is a hallmark feature of generalised anxiety disorder (GAD), associated with dysfunctional emotional..

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Brain alterations in low-frequency fluctuations across multiple bands in obsessive compulsive disorder

M Giménez, A Guinea-Izquierdo, V Villalta-Gil, I Martínez-Zalacaín, C Segalàs, M Subirà, E Real, J Pujol, BJ Harrison, JM Haro, JR Sato, MQ Hoexter, N Cardoner, P Alonso, JM Menchón, C Soriano-Mas

2017-12-01

The extent of functional abnormalities in frontal-subcortical circuits in obsessive-compulsive disorder (OCD) is still unclear. Al..

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Human ventromedial prefrontal cortex and the positive affective processing of safety signals

BJ Harrison, MA Fullana, E Via, C Soriano-Mas, B Vervliet, I Martínez-Zalacaín, J Pujol, CG Davey, T Kircher, B Straube, N Cardoner

2017-05-15

Human functional magnetic resonance imaging (fMRI) studies suggest that the ventromedial prefrontal cortex (vmPFC) contributes to ..

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Neural signatures of human fear conditioning: An updated and extended meta-analysis of fMRI studies

MA Fullana, BJ Harrison, C Soriano-Mas, B Vervliet, N Cardoner, A Àvila-Parcet, J Radua

2016-04-01

Classical Pavlovian fear conditioning remains the most widely employed experimental model of fear and anxiety, and continues to in..

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A neural mediator of human anxiety sensitivity

BJ Harrison, MA Fullana, C Soriano-Mas, E Via, J Pujol, I Martínez-Zalacaín, D Tinoco-Gonzalez, CG Davey, M López-Solà, V Pérez Sola, JM Menchón, N Cardoner

2015-10-01

Advances in the neuroscientific understanding of bodily autonomic awareness, or interoception, have led to the hypothesis that hum..